All Things in Moderation — Please!

All Things in Moderation: Prevention of Intestinal Adenomas by DNA Hypomethylation.

DNA hypomethylation can prevent intestinal tumorigenesis, presumably by reducing epigenetic silencing of tumor-suppressor genes. A study in this issue by Sheaffer and colleagues challenges this notion by showing that severe DNA hypomethylation by tissue-specific Dnmt1 knockout can actually promote intestinal adenoma formation. Cancer Prev Res; 9(7); 509-11. ©2016 AACRSee related article by Shea...

All Things to All People

Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.

Finding Awakening in All Things

As Santa Clara prepares to host the Dalai Lama on Monday, Feb. 24, it is worth examining the surprising parallels between the writings of St. Ignatius of Loyola—the founder of the Jesuit order—and a Buddhist text that played an important role in the spiritual formation of the Dalai Lama, The Way of the Bodhisattva by the eighth-century monk Śāntideva. While Ignatian spirituality and Tibetan Bud...

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EHPnet: All Things Toxic

When it is discovered that a toxicant in the environment may pose a threat to human health, a multitude of questions arise. People in the affected community want to know if they could have been exposed to the toxicant, and if so, whether they may get sick from the exposure, and how to avoid any risk the toxicant might pose. Physicians and epi-demiologists need current information on how to diag...